There's the field on the Configuration tab where you can punch in enemy physical hit damage. You can put some arbitrary values there that will affect the damage calculations on the Calcs tab. While the calculations currently show the overall mitigation percentage, they don't indicate in any way if the damage specified will exceed the current life total.
A simple warning in red like "Warning! Damage taken exceeds the current life pool by n hit points" below the table would be sufficient.
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